Research memoAstraZeneca PLC (AZN.L) · LSEMemo of October 10, 2026

AstraZeneca earnings: guidance and what to watch

AstraZeneca's next results are expected on October 30, 2026. Watch whether newer medicines replace revenue lost when older products lose exclusivity.

October 30, 2026
Next results
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Every number traced to AstraZeneca's filings8 chapters · 17,414 words252 sources cited

What has AstraZeneca guided for 2026?

Its 2026 outlook says earnings per share should grow faster than revenue. “Core” earnings are management’s adjusted view of ordinary performance; reported earnings include costs such as acquired-asset write-downs and certain legal charges. Constant-currency growth holds exchange rates steady, so currency movements do not disguise changes in demand.

The longer promise is at least 20 new medicines and $80 billion in annual revenue by 2030. Starting from 2025 revenue of $58.739 billion, that requires about 6.4% yearly growth. Etcamah was the eleventh medicine counted toward the launch ambition, but an approval is only permission to sell. Patients must be identified, treated and reimbursed before a launch becomes substantial revenue.

Guidance in force
PeriodLowHighGiven on
Total RevenueYear to Dec 2026Jul 27, 2026
Core EPSYear to Dec 2026Jul 27, 2026
Core Tax rateYear to Dec 202618.0%22.0%Jul 27, 2026
Total Revenue foreign-exchange impactYear to Dec 2026Jul 27, 2026
Core EPS foreign-exchange impactYear to Dec 2026Jul 27, 2026

Has AstraZeneca kept its past promises?

AstraZeneca promised annual revenue above $45 billion by 2023 while defending its independence during Pfizer’s takeover approach. It delivered $45.811 billion in 2023, although the result included Alexion. The newer ambition is $80 billion of revenue by 2030, adjusted for development risk and not dependent on future acquisitions. That makes the next test more revealing.

How have AstraZeneca's revenue and profit changed?

Revenue rose 6.4% to $15,384 million. Gross margin improved from 82.9% to 83.6%, so the pressure appeared below gross profit. Operating income fell from $3,508 million to $3,164 million, as higher research and administrative spending and $345 million of development-asset impairments weighed on the quarter.

Net income still rose to $2,507 million, while diluted EPS reached $1.61. The reported tax rate fell to about 10% from about 22%, which helped offset the weaker operating result. Core operating income improved, so the quarter contains both commercial progress and weaker reported expense performance.

The last eight reported periodsUS$ millions; per share in US$
Quarter to Jun 2026Quarter to Mar 2026Quarter to Dec 2025Quarter to Sep 2025Quarter to Jun 2025Quarter to Mar 2025Quarter to Dec 2024Quarter to Sep 2024
Revenue15,38415,28815,50315,19114,45713,58814,89113,565
Gross margin (calculated)83.6%82.5%79.9%81.6%82.9%83.5%81.7%77.3%
Operating income3,1644,2462,9783,5833,5083,6742,0362,106
Net income2,5073,0802,3262,5332,4502,9161,5001,429
EPS, diluted1.611.971.491.621.571.870.960.91
From the full memo · 1. The business

AstraZeneca is a pharmaceutical company: it turns scientific discoveries into prescription medicines and sells them through a healthcare system that sits between the company and the patient. To understand its business, follow a medicine from diagnosis to factory to payer, then follow the dollar back through research, manufacturing and partners.

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